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Lactate uptake by CD4 + T cells has been implicated in inhibiting migratory capability, essentially arresting T cells in the lactate hi microenvironment ( Figure 1 )

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Also, optogenetic stimulation of parvalbumin interneurons at 40 Hz restores hippocampal slow gamma oscillations amplitude, and phase-amplitude coupling of the J20 AD mouse model, resulting in the rescue of spatial memory in mice despite significant plaque deposition (Etter et al., 2019)