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A 2021 review in Frontiers in Pharmacology reports the research group using “10 μg, 10 ng, and 10 pg/kg” in rat models, given intraperitoneally once daily, in drinking water, or as a 1 μg/g topical cream

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35 are preclinical, and one is on a human trial, and so it was very limited in human research, so we got a lot of rats and dogs that were utilized for these studies